Directed by John Landis, An American Werewolf in London combines horror and comedy elements in a story about two American travelers in the UK. The film is known for its practical effects, which earned the Academy Award for Best Makeup. David Naughton and Jenny Agutter star in the lead roles. The film has since become associated with werewolf cinema and genre blending.

Arrow Films

One of the greatest directors of the 1980s, John Landis (The Blues Brothers, Trading Places), expertly combines macabre horror with dark humour in the lycanthropic classic, An American Werewolf in London.

American tourists David (David Naughton) and Jack (Griffin Dunne) are savaged by an unidentified vicious animal whilst hiking on the Yorkshire Moors. David awakes in a London hospital to find his friend dead and his life in disarray. Retiring to the home of a beautiful nurse (Jenny Agutter, Walkabout) to recuperate, he soon experiences disturbing changes to his mind and body, undergoing a full-moon transformation that will unleash terror on the streets of the capital...

An American Werewolf in London had audiences howling with laughter and recoiling in terror upon its cinema release. Landis' film has gone on to become one of the most important horror films of its decade, rightly lauded for its masterful set-pieces, uniquely unsettling atmosphere and Rick Baker's truly ground-breaking, Oscar-winning special make-up effects. Now restored and presented with an abundance of extra features, this big beast of horror can be devoured as never before...

Från IMDB:
American college students David Kessler and Jack Goodman on a walking tour of Britain are attacked by a werewolf that none of the locals will admit exists. Jack dies. David recovers in a hospital, where he has nightmares.