Blade: Trinity (2004)

Directed by David S. Goyer, Blade: Trinity stars Wesley Snipes as the vampire hunter Blade, who is forced to work with a group of human allies while being pursued by authorities. The story centers on a conflict involving the vampire leader Dracula.

Från IMDB:
Blade, now a wanted man by the FBI, must join forces with the Nightstalkers to face his most challenging enemy yet: Dracula.