Breakdown (1997)

Directed by Jonathan Mostow, Breakdown (1997) is an American thriller starring Kurt Russell and J. T. Walsh. The film follows a man whose wife disappears after accepting help from a truck driver in a remote desert area, leading to a tense search that reveals a criminal conspiracy. Set largely along isolated highways, the story builds suspense through pursuit, deception and escalating danger.

Från IMDB:
A man searches for his missing wife after his car breaks down in the middle of the desert.