I Am Legend is a 2007 American post-apocalyptic science fiction film directed by Francis Lawrence and starring Will Smith. Set in a depopulated New York City after a global viral outbreak, the story follows a military virologist who believes he may be the last human survivor while searching for a cure. The film adapts Richard Matheson’s novel and combines survival drama with infected-creature horror elements.

Från IMDB:
Years after a plague kills most of humanity and transforms the rest into monsters, the sole survivor in New York City struggles valiantly to find a cure.