Michael Mann’s Manhunter (1986), adapted from Thomas Harris’s novel Red Dragon, is the first screen appearance of Hannibal Lecter (here played by Brian Cox). Starring William Petersen as FBI profiler Will Graham, the film follows his hunt for the “Tooth Fairy” serial killer (Tom Noonan). With Mann’s neon-lit visual style and psychological depth, Manhunter has become a cult classic of serial killer cinema and a key entry in the Hannibal Lecter universe.

Från IMDB:
Former FBI profiler Will Graham returns to service to pursue a deranged serial killer dubbed "the Tooth Fairy" by the media.