Directed by Victor Salva, Jeepers Creepers (2001) follows siblings Trish and Darry after they encounter a mysterious creature while driving along isolated rural highways. Starring Gina Philips and Justin Long, the film combines road-based suspense, monster horror and supernatural terror as the pair become hunted by the ancient creature known as the Creeper.

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On a desolate country highway, two homeward-bound teens (Gina Philips - Chained, and Justin Long - Drag Me to Hell) are nearly run off the road by a maniac in a beat-up truck... and later spot him shoving what appears to be a body down a sewer pipe. But when they stop to investigate, they discover that the grisly reality at the bottom of that pipe is far worse than they could have ever suspected... and that they are now the targets of an evil far more unspeakable (and unstoppable) than they could have ever imagined!

Från IMDB:
A brother and sister driving home through isolated countryside for spring break encounter a flesh-eating creature which is in the midst of its ritualistic eating spree.